Actions of Esomeprazole on the Maternal Vasculature in Lean and Obese Pregnant Mice with Impaired Nitric Oxide Synthesis: A Model of Preeclampsia

N de Alwis; NK Binder; YTM Mangwiro; S Beard; N Pritchard; E Kadife; BR Fato; E Keenan; FC Brownfoot; TJ Kaitu’u-Lino; NJ Hannan

Journal article

Actions of Esomeprazole on the Maternal Vasculature in Lean and Obese Pregnant Mice with Impaired Nitric Oxide Synthesis: A Model of Preeclampsia

N de Alwis, NK Binder, YTM Mangwiro, S Beard, N Pritchard, E Kadife, BR Fato, E Keenan, FC Brownfoot, TJ Kaitu’u-Lino, NJ Hannan

International Journal of Molecular Sciences | Published : 2022

DOI: 10.3390/ijms23158185

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Abstract

Preeclampsia is a devastating, multisystem disorder of pregnancy. It has no cure except delivery, which if premature can impart significant neonatal morbidity. Efforts to repurpose pregnancy-safe therapeutics for the treatment of preeclampsia have led to the assessment of the proton pump inhibitor, esomeprazole. Preclinically, esomeprazole reduced placental secretion of anti-angiogenic sFlt-1, improved endothelial dysfunction, promoted vasorelaxation, and reduced maternal hypertension in a mouse model. Our understanding of the precise mechanisms through which esomeprazole works to reduce endothelial dysfunction and enhance vasoreactivity is limited. Evidence from earlier studies suggested es..

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University of Melbourne Researchers

Natasha de Alwis Author

Natalie Binder Author

Yeukai Mangwiro Author

Natasha Pritchard Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by the RANZCOG Women's Health Foundation Arthur Wilson Memorial Scholarship to N.P. National Health and Medical Research Council fellowship and scholarship support was provided to T.J.K.-L. (1159261), N.J.H. (1146128), and N.P. (1150828).